Tuesday, August 30, 2005

Possible cure for AIDS?

So we have this presentation in college, where we are given a movie and a related social issue which we have to present in front of the whole class. Initially, the idea was to screen the movie also, but this was not possible due to time constraints. The movie given to my group was ‘phir milenge’ and the social issue was AIDS.
Now my sub topic of research was Aids as a disease, its origin and its spread. The thing that makes the HIV virus so dangerous is an enzyme known as reverse transcriptase. What this does is that it changes the genetic matter of the virus from RNA to DNA and back again. This genetic switch keeps happening, so the organism basically changes at a fundamental genetic level. This is somewhat analogous to building a mouse trap, and suddenly the mouse transforms into a snake. Therefore reverse transcriptase is one of the most dangerous things known to mankind. It changes the virus, and that is why AIDS does not have a cure as of now.
The approach of research now is to find innovative ways to recognize the virus. Now this in itself is pretty useless, as it cannot cure all the existing AIDS cases. The HIV virus degrades the immune system, and the degraded immune system cannot be reinstated. But what such research can do is either vaccinate the body before the virus sets in, or combat the virus before AIDS sets in. Nanobot technology is not too far away, and the talk is that nanobots will help cure AIDS, as well as create an artificial immune system.
I don’t know if there is any research in this direction, but I think I have an unexplored possibility for finding a cure. It basically involves combating the enzyme instead of the virus. Detecting and deactivating the enzyme could possible be the cure. As I understand, enzymes are volatile substances and are easy to disintegrate or modify in a reaction. Sending a normal cleanup medicine behind the deactivator to eradicate the deactivated HIV cells could help. There is a good eight years to do this, before AIDS sets in. A major hurdle would be that the enzymes are very substrate specific, so it would be difficult, but not impossible, and therefore worthwhile to find something that will act on them.

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